The 1960s saw explosive growth. Northside enrollment doubled in the first three years of the decade, and doubled again by 1967. By the end of the 60s, Northside enrolled over 20,000 students and had opened 12 new elementary schools, two new middle schools, and two new high schools. In 1964, Murray Boone retired as superintendent, and the school board selected Edmund Cody.
In 1966, Northside fully embraced integration with the closing of West San Antonio Heights and the transfer of African American students to ten elementary schools. The board also started Northside's bilingual education program with summer school classes for non-English speaking children. They began Northside's special education program by approving the education of all children, regardless of their handicaps.